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兴发pt登录学报,2019,36(9):10-13https://doi.org/10.16039/j.cnki.cn22-1249.2019.09.003
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多酸抗肿瘤药物淀粉微粒的制备与表征
曲小姝,石丹,张丽,刘岩
兴发pt登录 化学与制药工程学院
Starch-based Microparticles of Polyoxometalate Antitumor Drug:Preparation and Characteristics
Qu Xiaoshu, Shi Dan, Zhang Li, Liu Yan
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摘要

本文以可溶性淀粉为载体,环氧氯丙烷为交联剂,采用反相微乳液法制备了一种多金属氧酸盐抗肿瘤药物传递系统: K14[NaP5W29O107]·40H2O淀粉微粒(简称P5W29-CSM)。探索了P5W29-CSM的制备工艺,通过扫描电子显微镜(SEM)、红外光谱(IR)、X-射线粉末衍射(XRD)对合成的微粒给药系统进行了形貌和结构表征,并通过紫外分光光度法测得其载药量为4.9%。

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曲小姝
石丹
张丽
刘岩
关键词:多酸抗肿瘤淀粉微粒制备
Abstract:

A polyoxometalate antitumor drug delivery system, K14[NaP5W29O107]·40H2O starch-based microparticles (P5W29-CSM for short), have been prepared by the inverse emulsion method using soluble starch as raw material, epichlorohydrin as crosslinker. The preparation process of starch microspheres drug delivery was explored and determined. The structure of P5W29-CSM was characterized by SEM, IR, X-ray powder diffraction and UV-visible spectroscopy. The content of polyoxometalate in P5W29-CSM was 4.9% which is determined by UV spectrophotometry.

Key words:polyoxometalateantitumorstarch microparticlespreparation
出版日期:2019-09-25发布日期:2019-09-25整期出版日期:2019-09-25
ZTFLH: O635.2
引用本文:
曲小姝, 石丹, 张丽, 刘岩. 多酸抗肿瘤药物淀粉微粒的制备与表征 [J]. 兴发pt登录学报, 2019, 36(9): 10-13.
Qu Xiaoshu, Shi Dan, Zhang Li, Liu Yan. Starch-based Microparticles of Polyoxometalate Antitumor Drug:Preparation and Characteristics . Journal of Jilin Institute of Chemical Technology, 2019, 36(9): 10-13.
链接本文:
http://xuebao.jlict.edu.cn/CN/10.16039/j.cnki.cn22-1249.2019.09.003http://xuebao.jlict.edu.cn/CN/Y2019/V36/I9/10
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